3DY7

X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP

3DY7 の概要

• エントリーDOI: 10.2210/pdb3dy7/pdb
• 関連するPDBエントリー: 1S9I 1S9J
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: dual specificity protein kinase, non-atp-competitive kinase inhibitor, inhibitor-bound protein kinase, atp-bound protein kinase, acetylation, atp-binding, disease mutation, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, tyrosine-protein kinase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38914.26

構造登録者

Ohren, J.F.,Pavlovsky, A.,Zhang, E. (登録日: 2008-07-25, 公開日: 2009-06-16, 最終更新日: 2023-08-30)

• 主引用文献: Tecle, H.,Shao, J.,Li, Y.,Kothe, M.,Kazmirski, S.,Penzotti, J.,Ding, Y.H.,Ohren, J.,Moshinsky, D.,Coli, R.,Jhawar, N.,Bora, E.,Jacques-O'Hagan, S.,Wu, J.; Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?; Bioorg.Med.Chem.Lett., 19:226-229, 2009; PubMed: 19019675; DOI: 10.1016/j.bmcl.2008.10.108

実験手法

X-RAY DIFFRACTION (2.7 Å)