3DY6

PPARdelta complexed with an anthranilic acid partial agonist

Summary for 3DY6

Entry DOI	10.2210/pdb3dy6/pdb
Related	1gwx
Descriptor	Peroxisome proliferator-activated receptor delta, IODIDE ION, 2-({[3-(3,4-dihydroisoquinolin-2(1H)-ylsulfonyl)phenyl]carbonyl}amino)benzoic acid, ... (4 entities in total)
Functional Keywords	ppar, nulear receptor, activator, dna-binding, metal-binding, nucleus, transcription, transcription regulation, zinc-finger
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q03181
Total number of polymer chains	2
Total formula weight	63033.99
Authors	Lambert, M.L.,Xu, R.,Shearer, B.G.,Wilson, T.M. (deposition date: 2008-07-25, release date: 2008-10-07, Last modification date: 2023-08-30)
Primary citation	Shearer, B.G.,Patel, H.S.,Billin, A.N.,Way, J.M.,Winegar, D.A.,Lambert, M.H.,Xu, R.X.,Leesnitzer, L.M.,Merrihew, R.V.,Huet, S.,Willson, T.M. Discovery of a novel class of PPARdelta partial agonists Bioorg.Med.Chem.Lett., 18:5018-5022, 2008 Cited by PubMed Abstract: Anthranilic acid GW9371 was identified as a novel class of PPARdelta partial agonist through high-throughput screening. The design and synthesis of SAR analogues is described. GSK1115 and GSK7227 show potent partial agonism of the PPARdelta target genes CPT1a and PDK4 in skeletal muscle cells. PubMed: 18722772 DOI: 10.1016/j.bmcl.2008.08.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation