3DWF

Crystal Structure of the Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1 Mutant F278E

Summary for 3DWF

Entry DOI	10.2210/pdb3dwf/pdb
Descriptor	11-beta-hydroxysteroid dehydrogenase 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ... (5 entities in total)
Functional Keywords	rossmann fold, short chain dehydrogenase reductase, sdr, endoplasmic reticulum, glycoprotein, lipid metabolism, membrane, nadp, oxidoreductase, signal-anchor, steroid metabolism, transmembrane
Biological source	Cavia porcellus (Guinea pig)
Cellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein: Q6QLL4
Total number of polymer chains	4
Total formula weight	125635.44
Authors	Lawson, A.J.,Ride, J.P.,White, S.A.,Walker, E.A. (deposition date: 2008-07-22, release date: 2009-08-11, Last modification date: 2024-02-21)
Primary citation	Lawson, A.J.,Walker, E.A.,White, S.A.,Dafforn, T.R.,Stewart, P.M.,Ride, J.P. Mutations of key hydrophobic surface residues of 11 beta-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system Protein Sci., 18:1552-1563, 2009 Cited by PubMed: 19507261 DOI: 10.1002/pro.150 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation