3DWF
Crystal Structure of the Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1 Mutant F278E
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 11-beta-hydroxysteroid dehydrogenase 1 | polymer | 276 | 30361.2 | 4 | UniProt (Q6QLL4) Pfam (PF00106) | Cavia porcellus (Guinea pig) | Corticosteroid 11-beta-dehydrogenase isozyme 1, 11-DH, 11-beta-HSD1 |
| 2 | E, H, L, O (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 3 | F, I, M, N, P (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 4 | G, J, K, Q, R... (A, B, D) | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
| 5 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 452 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 24 - 299 (UniProt: Q6QLL4)
| PDB | External Database | Details |
|---|---|---|
| Glu 278 | Phe 278 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 121444.8 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 4190.7 | |
| All* | Total formula weight | 125635.4 |
