3DWF
Crystal Structure of the Guinea Pig 11beta-Hydroxysteroid Dehydrogenase Type 1 Mutant F278E
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | 11-beta-hydroxysteroid dehydrogenase 1 | polymer | 276 | 30361.2 | 4 | UniProt (Q6QLL4) Pfam (PF00106) In PDB | Cavia porcellus (Guinea pig) | Corticosteroid 11-beta-dehydrogenase isozyme 1, 11-DH, 11-beta-HSD1 |
2 | A, B, C, D | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
3 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
4 | A, B, D | GLYCEROL | non-polymer | 92.1 | 8 | Chemie (GOL) | |||
5 | water | water | 18.0 | 452 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 24 - 299 (UniProt: Q6QLL4)
PDB | External Database | Details |
---|---|---|
Glu 278 | Phe 278 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 121444.8 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 4190.7 | |
All* | Total formula weight | 125635.4 |