3DR1

Side-chain fluorine atoms of non-steroidal vitamin D3 analogs stabilize helix 12 of vitamin D receptor

Summary for 3DR1

Entry DOI	10.2210/pdb3dr1/pdb
Descriptor	Vitamin D3 receptor A, SRC-1 (LXXLL motif) from Nuclear receptor coactivator 1, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	gene regulation, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc, zinc-finger, activator, acyltransferase, alternative splicing, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, gene regulation-transferase complex, gene regulation/transferase
Biological source	Danio rerio (zebra fish) More
Cellular location	Nucleus: Q9PTN2 Nucleus (By similarity): Q15788
Total number of polymer chains	2
Total formula weight	36343.55
Authors	Sato, Y.,Rochel, N.,Moras, D. (deposition date: 2008-07-10, release date: 2009-06-16, Last modification date: 2023-11-01)
Primary citation	Eelen, G.,Valle, N.,Sato, Y.,Rochel, N.,Verlinden, L.,De Clercq, P.,Moras, D.,Bouillon, R.,Munoz, A.,Verstuyf, A. Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor. Chem.Biol., 15:1029-1034, 2008 Cited by PubMed: 18940664 DOI: 10.1016/j.chembiol.2008.08.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation