3DR1

Side-chain fluorine atoms of non-steroidal vitamin D3 analogs stabilize helix 12 of vitamin D receptor

3DR1 の概要

分子名称Vitamin D3 receptor A, SRC-1 (LXXLL motif) from Nuclear receptor coactivator 1, MAGNESIUM ION, ... (5 entities in total)
機能のキーワードgene regulation, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc, zinc-finger, activator, acyltransferase, alternative splicing, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, gene regulation-transferase complex, gene regulation/transferase
由来する生物種Danio rerio (zebra fish)
詳細
細胞内の位置Nucleus Q9PTN2
Nucleus (By similarity) Q15788
ポリマー鎖数2
分子量合計36343.55
構造登録者
Sato, Y.,Rochel, N.,Moras, D. (登録日: 2008-07-10, 公開日: 2009-06-16, 最終更新日: 2011-07-13)
主引用文献
Eelen, G.,Valle, N.,Sato, Y.,Rochel, N.,Verlinden, L.,De Clercq, P.,Moras, D.,Bouillon, R.,Munoz, A.,Verstuyf, A.
Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.
Chem.Biol., 15:1029-1034, 2008
PubMed: 18940664 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.chembiol.2008.08.008
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.7 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers180.8%5.3%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード