3DR1

Side-chain fluorine atoms of non-steroidal vitamin D3 analogs stabilize helix 12 of vitamin D receptor

3DR1 の概要

• エントリーDOI: 10.2210/pdb3dr1/pdb
• 分子名称: Vitamin D3 receptor A, SRC-1 (LXXLL motif) from Nuclear receptor coactivator 1, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: gene regulation, dna-binding, metal-binding, nucleus, receptor, transcription, transcription regulation, zinc, zinc-finger, activator, acyltransferase, alternative splicing, chromosomal rearrangement, phosphoprotein, polymorphism, proto-oncogene, transferase, ubl conjugation, gene regulation-transferase complex, gene regulation/transferase
• 由来する生物種: Danio rerio (zebra fish); 詳細
• 細胞内の位置: Nucleus: Q9PTN2; Nucleus (By similarity): Q15788
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 36343.55

構造登録者

Sato, Y.,Rochel, N.,Moras, D. (登録日: 2008-07-10, 公開日: 2009-06-16, 最終更新日: 2023-11-01)

• 主引用文献: Eelen, G.,Valle, N.,Sato, Y.,Rochel, N.,Verlinden, L.,De Clercq, P.,Moras, D.,Bouillon, R.,Munoz, A.,Verstuyf, A.; Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.; Chem.Biol., 15:1029-1034, 2008; PubMed: 18940664; DOI: 10.1016/j.chembiol.2008.08.008

実験手法

X-RAY DIFFRACTION (2.7 Å)