3DQW

c-Src kinase domain Thr338Ile mutant in complex with ATPgS

3DQW の概要

• エントリーDOI: 10.2210/pdb3dqw/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: src, kinase, active, gatekeeper, atp-binding, lipoprotein, myristate, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, sh3 domain, transferase, tyrosine-protein kinase
• 由来する生物種: Gallus gallus (chicken)
• 細胞内の位置: Cell membrane (By similarity): P00523
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 133464.91

構造登録者

Azam, M.,Seeliger, M.A.,Gray, N.,Kuriyan, J.,Daley, G.Q. (登録日: 2008-07-09, 公開日: 2008-09-23, 最終更新日: 2023-11-15)

• 主引用文献: Azam, M.,Seeliger, M.A.,Gray, N.S.,Kuriyan, J.,Daley, G.Q.; Activation of tyrosine kinases by mutation of the gatekeeper threonine.; Nat.Struct.Mol.Biol., 15:1109-1118, 2008; PubMed: 18794843; DOI: 10.1038/nsmb.1486

実験手法

X-RAY DIFFRACTION (2.017 Å)