3DPK
cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor
3DPK の概要
エントリーDOI | 10.2210/pdb3dpk/pdb |
関連するPDBエントリー | 2i0v 2i1m 2ogv 3bea |
分子名称 | Macrophage colony-stimulating factor 1 receptor, Fibroblast growth factor receptor 1, SULFATE ION, 8-cyclohexyl-N-methoxy-5-oxo-2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, ... (4 entities in total) |
機能のキーワード | receptor tyrosine kinase, kinase-inhibitor complex, atp-binding, glycoprotein, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase, craniosynostosis, disease mutation, dwarfism, heparin-binding, kallmann syndrome |
由来する生物種 | Homo sapiens (human) 詳細 |
細胞内の位置 | Cell membrane; Single-pass type I membrane protein: P07333 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 38843.26 |
構造登録者 | |
主引用文献 | Huang, H.,Hutta, D.A.,Rinker, J.M.,Hu, H.,Parsons, W.H.,Schubert, C.,DesJarlais, R.L.,Crysler, C.S.,Chaikin, M.A.,Donatelli, R.R.,Chen, Y.,Cheng, D.,Zhou, Z.,Yurkow, E.,Manthey, C.L.,Player, M.R. Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors J.Med.Chem., 52:1081-1099, 2009 Cited by PubMed: 19193011DOI: 10.1021/jm801406h 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.95 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード