3DPK

cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor

Summary for 3DPK

• Entry DOI: 10.2210/pdb3dpk/pdb
• Related: 2i0v 2i1m 2ogv 3bea
• Descriptor: Macrophage colony-stimulating factor 1 receptor, Fibroblast growth factor receptor 1, SULFATE ION, 8-cyclohexyl-N-methoxy-5-oxo-2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, ... (4 entities in total)
• Functional Keywords: receptor tyrosine kinase, kinase-inhibitor complex, atp-binding, glycoprotein, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase, craniosynostosis, disease mutation, dwarfism, heparin-binding, kallmann syndrome
• Biological source: Homo sapiens (human); More
• Cellular location: Cell membrane; Single-pass type I membrane protein: P07333
• Total number of polymer chains: 1
• Total formula weight: 38843.26

Authors

Schubert, C. (deposition date: 2008-07-08, release date: 2009-02-17, Last modification date: 2023-08-30)

• Primary citation: Huang, H.,Hutta, D.A.,Rinker, J.M.,Hu, H.,Parsons, W.H.,Schubert, C.,DesJarlais, R.L.,Crysler, C.S.,Chaikin, M.A.,Donatelli, R.R.,Chen, Y.,Cheng, D.,Zhou, Z.,Yurkow, E.,Manthey, C.L.,Player, M.R.; Pyrido[2,3-d]pyrimidin-5-ones: a novel class of antiinflammatory macrophage colony-stimulating factor-1 receptor inhibitors; J.Med.Chem., 52:1081-1099, 2009; PubMed: 19193011; DOI: 10.1021/jm801406h

Experimental method

X-RAY DIFFRACTION (1.95 Å)