3DPK
cFMS tyrosine kinase in complex with a pyridopyrimidinone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Macrophage colony-stimulating factor 1 receptor, Fibroblast growth factor receptor 1 | polymer | 335 | 38064.5 | 1 | UniProt (P07333) UniProt (P11362) Pfam (PF07714) | Homo sapiens (human) | CSF-1 receptor, CSF-1-R, CSF-1R, M-CSF-R, Proto-oncogene c-Fms, FGFR-1, Basic fibroblast growth factor receptor 1, BFGFR, bFGF-R-1, Fms-like tyrosine kinase 2, FLT-2, N-sam, Proto-oncogene c-Fgr |
| 2 | B, C, D (A) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E (A) | 8-cyclohexyl-N-methoxy-5-oxo-2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | non-polymer | 490.6 | 1 | Chemie (8C5) | |||
| 4 | F (A) | water | water | 18.0 | 123 | Chemie (HOH) |
Sequence modifications
A: 538 - 678 (UniProt: P07333)
A: 679 - 699 (UniProt: P11362)
A: 753 - 922 (UniProt: P07333)
| PDB | External Database | Details |
|---|---|---|
| Gly 535 | - | expression tag |
| Val 536 | - | expression tag |
| Asp 537 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 686 | Cys 584 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38064.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 778.8 | |
| All* | Total formula weight | 38843.3 |
