3DOX

X-ray structure of HIV-1 protease in situ product complex

3DOX の概要

• エントリーDOI: 10.2210/pdb3dox/pdb
• 関連するPDBエントリー: 1G6L 1LV1 2NPH
• 分子名称: HIV-1 PROTEASE, A PEPTIDE SUBSTRATE-SQNY, A PEPTIDE SUBSTRATE-PIV, ... (4 entities in total)
• 機能のキーワード: hiv-1 protease; transition state; reaction intermediate; catalysis; inhibitor; x-ray crystallography, aids, aspartyl protease, capsid maturation, capsid protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, host-virus interaction, hydrolase, lipoprotein, magnesium, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, ribosomal frameshifting, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger
• 由来する生物種: Human immunodeficiency virus type 1 (isolate HXB2 group M subtype B) (HIV-1, HIV-1 M:B_HXB2R); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 22740.68

構造登録者

Hosur, M.V.,Ferrer, J.-L.,Das, A.,Prashar, V.,Bihani, S. (登録日: 2008-07-07, 公開日: 2008-09-09, 最終更新日: 2021-11-10)

• 主引用文献: Bihani, S.,Das, A.,Prashar, V.,Ferrer, J.-L.,Hosur, M.V.; X-ray structure of HIV-1 protease in situ product complex; Proteins, 74:594-602, 2009; PubMed: 18704947; DOI: 10.1002/prot.22174

実験手法

X-RAY DIFFRACTION (2 Å)