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3DKO

Complex between the kinase domain of human ephrin type-a receptor 7 (epha7) and inhibitor alw-ii-49-7

Summary for 3DKO
Entry DOI10.2210/pdb3dko/pdb
Related2REI
DescriptorEphrin type-A receptor 7, 5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide (3 entities in total)
Functional Keywordsatp-binding, kinase, nucleotide-binding, receptor, transferase, phosphorylation, transmembrane, tyrosine-protein kinase, alternative splicing, glycoprotein, inhibitor, structural genomics consortium, sgc, membrane, phosphoprotein, polymorphism, nppsfa, national project on protein structural and functional analyses
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane ; Single-pass type I membrane protein : Q15375
Total number of polymer chains1
Total formula weight36653.91
Authors
Primary citationWalker, J.R.,Syeda, F.,Gray, N.,Butler-Cole, C.,Bountra, C.,Wolkstrom, M.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.
Kinase domain of human ephrin type-a receptor 7 (epha7) in complex with ALW-II-49-7
To be Published,
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

PDB entries from 2024-03-27

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