3DKC

Structure of MET receptor tyrosine kinase in complex with ATP

3DKC の概要

• エントリーDOI: 10.2210/pdb3dkc/pdb
• 関連するPDBエントリー: 3DKF 3DKG
• 分子名称: Hepatocyte growth factor receptor, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: drug discovery, c-met kinase, fragment based, membrane, receptor, transmembrane, oncoprotein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36317.29

構造登録者

Hendle, J. (登録日: 2008-06-24, 公開日: 2009-07-07, 最終更新日: 2024-02-21)

• 主引用文献: Buchanan, S.G.,Hendle, J.,Lee, P.S.,Smith, C.R.,Bounaud, P.Y.,Jessen, K.A.,Tang, C.M.,Huser, N.H.,Felce, J.D.,Froning, K.J.,Peterman, M.C.,Aubol, B.E.,Gessert, S.F.,Sauder, J.M.,Schwinn, K.D.,Russell, M.,Rooney, I.A.,Adams, J.,Leon, B.C.,Do, T.H.,Blaney, J.M.,Sprengeler, P.A.,Thompson, D.A.,Smyth, L.,Pelletier, L.A.,Atwell, S.,Holme, K.,Wasserman, S.R.,Emtage, S.,Burley, S.K.,Reich, S.H.; SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.; Mol.Cancer Ther., 8:3181-3190, 2009; PubMed: 19934279; DOI: 10.1158/1535-7163.MCT-09-0477

実験手法

X-RAY DIFFRACTION (1.52 Å)