3DK1

Wild Type HIV-1 Protease with potent Antiviral inhibitor GRL-0105A

3DK1 の概要

• エントリーDOI: 10.2210/pdb3dk1/pdb
• 関連するPDBエントリー: 2HB3 2IEN 2Z4O 3DJK
• 分子名称: Protease, SODIUM ION, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: hiv-1, wild type protease, protease inhibitor, hydrolase, aids, aspartyl protease, capsid maturation, capsid protein, cytoplasm, dna integration, dna recombination, dna-directed dna polymerase, endonuclease, lipoprotein, magnesium, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, nucleus, phosphoprotein, protease, ribosomal frameshifting, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, zinc, zinc-finger
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1)
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22187.40

構造登録者

Wang, Y.F.,Weber, I.T. (登録日: 2008-06-24, 公開日: 2009-05-12, 最終更新日: 2023-11-01)

• 主引用文献: Ghosh, A.K.,Gemma, S.,Takayama, J.,Baldridge, A.,Leshchenko-Yashchuk, S.,Miller, H.B.,Wang, Y.F.,Kovalevsky, A.Y.,Koh, Y.,Weber, I.T.,Mitsuya, H.; Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies; Org.Biomol.Chem., 6:3703-3713, 2008; PubMed: 18843400; DOI: 10.1039/b809178a

実験手法

X-RAY DIFFRACTION (1.07 Å)