3DI2

Crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain

Summary for 3DI2

Entry DOI	10.2210/pdb3di2/pdb
Related	3DI3
Descriptor	Interleukin-7, Interleukin-7 receptor subunit alpha, PENTAETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	interleukin, cytokine, cytokine receptor, ectodomain, glycoprotein, growth factor, secreted, alternative splicing, disease mutation, membrane, phosphoprotein, polymorphism, receptor, scid, transmembrane, cytokine-cytokine receptor complex, cytokine/cytokine receptor
Biological source	Homo sapiens (Human) More
Cellular location	Secreted: P13232 Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cell membrane; Single-pass type I membrane protein. Isoform 4: Secreted: P16871
Total number of polymer chains	4
Total formula weight	86711.22
Authors	McElroy, C.A.,Dohm, J.A.,Walsh, S.T.R. (deposition date: 2008-06-19, release date: 2009-01-27, Last modification date: 2021-10-20)
Primary citation	McElroy, C.A.,Dohm, J.A.,Walsh, S.T. Structural and Biophysical Studies of the Human IL-7/IL-7Ralpha Complex. Structure, 17:54-65, 2009 Cited by PubMed: 19141282 DOI: 10.1016/j.str.2008.10.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation