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3DI2

Crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain

Functional Information from GO Data
ChainGOidnamespacecontents
A0001961biological_processpositive regulation of cytokine-mediated signaling pathway
A0002360biological_processT cell lineage commitment
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005139molecular_functioninterleukin-7 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006955biological_processimmune response
A0006959biological_processhumoral immune response
A0007267biological_processcell-cell signaling
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0009887biological_processanimal organ morphogenesis
A0010468biological_processregulation of gene expression
A0010628biological_processpositive regulation of gene expression
A0019221biological_processcytokine-mediated signaling pathway
A0030890biological_processpositive regulation of B cell proliferation
A0032722biological_processpositive regulation of chemokine production
A0035265biological_processorgan growth
A0038111biological_processinterleukin-7-mediated signaling pathway
A0042100biological_processB cell proliferation
A0043066biological_processnegative regulation of apoptotic process
A0045453biological_processbone resorption
A0045579biological_processpositive regulation of B cell differentiation
A0045582biological_processpositive regulation of T cell differentiation
A0046622biological_processpositive regulation of organ growth
A0048873biological_processhomeostasis of number of cells within a tissue
A0050730biological_processregulation of peptidyl-tyrosine phosphorylation
A0062023cellular_componentcollagen-containing extracellular matrix
A0097191biological_processextrinsic apoptotic signaling pathway
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
A2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
B0004896molecular_functioncytokine receptor activity
B0016020cellular_componentmembrane
C0001961biological_processpositive regulation of cytokine-mediated signaling pathway
C0002360biological_processT cell lineage commitment
C0005125molecular_functioncytokine activity
C0005126molecular_functioncytokine receptor binding
C0005139molecular_functioninterleukin-7 receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006955biological_processimmune response
C0006959biological_processhumoral immune response
C0007267biological_processcell-cell signaling
C0008083molecular_functiongrowth factor activity
C0008284biological_processpositive regulation of cell population proliferation
C0009887biological_processanimal organ morphogenesis
C0010468biological_processregulation of gene expression
C0010628biological_processpositive regulation of gene expression
C0019221biological_processcytokine-mediated signaling pathway
C0030890biological_processpositive regulation of B cell proliferation
C0032722biological_processpositive regulation of chemokine production
C0035265biological_processorgan growth
C0038111biological_processinterleukin-7-mediated signaling pathway
C0042100biological_processB cell proliferation
C0043066biological_processnegative regulation of apoptotic process
C0045453biological_processbone resorption
C0045579biological_processpositive regulation of B cell differentiation
C0045582biological_processpositive regulation of T cell differentiation
C0046622biological_processpositive regulation of organ growth
C0048873biological_processhomeostasis of number of cells within a tissue
C0050730biological_processregulation of peptidyl-tyrosine phosphorylation
C0062023cellular_componentcollagen-containing extracellular matrix
C0097191biological_processextrinsic apoptotic signaling pathway
C2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
C2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
D0004896molecular_functioncytokine receptor activity
D0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE 1PE A 340
ChainResidue
AASP8
AASN91

Functional Information from PROSITE/UniProt
site_idPS00255
Number of Residues10
DetailsINTERLEUKIN_7_9 Interleukin-7 and -9 signature. NdLCFLKrLL
ChainResidueDetails
AASN126-LEU135

site_idPS01355
Number of Residues32
DetailsHEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. LqpaamyeikVRsipdhyfkgf..........WSeWSpsyyF
ChainResidueDetails
BLEU175-PHE206

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues436
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLU1-ASP219
DGLU1-ASP219
AASN116
CASN70
CASN91
CASN116

site_idSWS_FT_FI2
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19141282
ChainResidueDetails
BASN29
BASN45
BASN131
DASN29
DASN45
DASN131

site_idSWS_FT_FI3
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN162
BASN212
BASN213
DASN162
DASN212
DASN213

222036

PDB entries from 2024-07-03

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