3DI2

Crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001961	biological_process	positive regulation of cytokine-mediated signaling pathway
A	0005125	molecular_function	cytokine activity
A	0005126	molecular_function	cytokine receptor binding
A	0005139	molecular_function	interleukin-7 receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006955	biological_process	immune response
A	0006959	biological_process	humoral immune response
A	0007267	biological_process	cell-cell signaling
A	0008083	molecular_function	growth factor activity
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009887	biological_process	animal organ morphogenesis
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0030890	biological_process	positive regulation of B cell proliferation
A	0031012	cellular_component	extracellular matrix
A	0032722	biological_process	positive regulation of chemokine production
A	0038111	biological_process	interleukin-7-mediated signaling pathway
A	0043066	biological_process	negative regulation of apoptotic process
A	0045453	biological_process	bone resorption
A	0045582	biological_process	positive regulation of T cell differentiation
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane
C	0001961	biological_process	positive regulation of cytokine-mediated signaling pathway
C	0005125	molecular_function	cytokine activity
C	0005126	molecular_function	cytokine receptor binding
C	0005139	molecular_function	interleukin-7 receptor binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006955	biological_process	immune response
C	0006959	biological_process	humoral immune response
C	0007267	biological_process	cell-cell signaling
C	0008083	molecular_function	growth factor activity
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009887	biological_process	animal organ morphogenesis
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0030890	biological_process	positive regulation of B cell proliferation
C	0031012	cellular_component	extracellular matrix
C	0032722	biological_process	positive regulation of chemokine production
C	0038111	biological_process	interleukin-7-mediated signaling pathway
C	0043066	biological_process	negative regulation of apoptotic process
C	0045453	biological_process	bone resorption
C	0045582	biological_process	positive regulation of T cell differentiation
D	0004896	molecular_function	cytokine receptor activity
D	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE A 340

Chain	Residue
A	ASP8
A	ASN91

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Functional Information from PROSITE/UniProt

site_id	PS00255
Number of Residues	10
Details	INTERLEUKIN_7_9 Interleukin-7 and -9 signature. NdLCFLKrLL

Chain	Residue	Details
A	ASN126-LEU135

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site_id	PS01355
Number of Residues	32
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. LqpaamyeikVRsipdhyfkgf..........WSeWSpsyyF

Chain	Residue	Details
B	LEU175-PHE206

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	100
Details	Domain: {"description":"Fibronectin type-III","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19141282","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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