3DI2
Crystal structure of the complex of human interleukin-7 with unglycosylated human interleukin-7 receptor alpha ectodomain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Interleukin-7 | polymer | 154 | 17545.5 | 2 | UniProt (P13232) Pfam (PF01415) | Homo sapiens (Human) | IL-7 |
| 2 | B, D (B, D) | Interleukin-7 receptor subunit alpha | polymer | 223 | 25691.0 | 2 | UniProt (P16871) Pfam (PF18447) Pfam (PF00041) | Homo sapiens (Human) | IL-7R-alpha, CD127 antigen, CDw127 |
| 3 | E (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 4 | F, G, H, I (A, B, C, D) | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 152 (UniProt: P13232)
B, D: 1 - 219 (UniProt: P16871)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ala 106 | Glu 131 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| His -1 | - | expression tag |
| Met 0 | - | expression tag |
| Val 118 | Ile 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 86472.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 238.3 | |
| All* | Total formula weight | 86711.2 |
