3DGR
Crystal structure of human NAMPT complexed with ADP analogue
Summary for 3DGR
Entry DOI | 10.2210/pdb3dgr/pdb |
Related | 3DHD 3DHF 3DKJ 3DKL |
Descriptor | Nicotinamide phosphoribosyltransferase, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER (3 entities in total) |
Functional Keywords | transferase, nmprtase, visfatin, adenosine 5'-(alpha, beta-methylene)diphosphate, alternative splicing, cytoplasm, glycosyltransferase, phosphoprotein, polymorphism, pyridine nucleotide biosynthesis |
Biological source | Homo sapiens |
Cellular location | Nucleus : P43490 |
Total number of polymer chains | 2 |
Total formula weight | 110460.67 |
Authors | Ho, M.,Burgos, E.S.,Almo, S.C.,Schramm, V.L. (deposition date: 2008-06-15, release date: 2009-08-18, Last modification date: 2023-08-30) |
Primary citation | Burgos, E.S.,Ho, M.C.,Almo, S.C.,Schramm, V.L. A phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPT. Proc.Natl.Acad.Sci.USA, 106:13748-13753, 2009 Cited by PubMed: 19666527DOI: 10.1073/pnas.0903898106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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