3DDP

Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8

3DDP の概要

• エントリーDOI: 10.2210/pdb3ddp/pdb
• 関連するPDBエントリー: 3DDQ
• 分子名称: Cell division protein kinase 2, Cyclin-A2, (2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol, ... (4 entities in total)
• 機能のキーワード: ser/thr protein kinase; phosphorylation; cell cycle, atp-binding, cell division, mitosis, nucleotide-binding, phosphoprotein, polymorphism, serine/threonine-protein kinase, cyclin, cytoplasm, nucleus, transferase-cell cycle complex, transferase/cell cycle
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: P30274
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 130845.16

構造登録者

Echalier, A.,Endicott, J.A. (登録日: 2008-06-06, 公開日: 2008-07-22, 最終更新日: 2011-07-13)

• 主引用文献: Bettayeb, K.,Oumata, N.,Echalier, A.,Ferandin, Y.,Endicott, J.A.,Galons, H.,Meijer, L.; CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.; Oncogene, 27:5797-5807, 2008; PubMed: 18574471; DOI: 10.1038/onc.2008.191

実験手法

X-RAY DIFFRACTION (2.7 Å)