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3DBF

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 562

Summary for 3DBF
Entry DOI10.2210/pdb3dbf/pdb
Related3d5w 3db6 3db8 3dbc 3dbd 3dbe
DescriptorPolo-like kinase, 4-({1-[3-(3-amino-3-oxopropyl)-5-chlorophenyl]-3-methyl-1H-pyrazolo[4,3-c]pyridin-6-yl}amino)-3-methoxy-N-(1-methylpipe ridin-4-yl)benzamide (3 entities in total)
Functional Keywordspolo-like kinase 1, plk1, catalytic domain, small-molecule inhibitor, kinase, transferase
Biological sourceDanio rerio (Zebrafish)
Total number of polymer chains1
Total formula weight35018.20
Authors
Elling, R.A.,Zhu, J.,Barr, K.J.,Romanowski, M.J. (deposition date: 2008-05-31, release date: 2008-10-07, Last modification date: 2023-08-30)
Primary citationFucini, R.V.,Hanan, E.J.,Romanowski, M.J.,Elling, R.A.,Lew, W.,Barr, K.J.,Zhu, J.,Yoburn, J.C.,Liu, Y.,Fahr, B.T.,Fan, J.,Lu, Y.,Pham, P.,Choong, I.C.,VanderPorten, E.C.,Bui, M.,Purkey, H.E.,Evanchik, M.J.,Yang, W.
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Bioorg.Med.Chem.Lett., 18:5648-5652, 2008
Cited by
PubMed: 18793847
DOI: 10.1016/j.bmcl.2008.08.095
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.2 Å)
Structure validation

217705

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