3DBF
Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 562
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polo-like kinase | polymer | 301 | 34442.1 | 1 | UniProt (Q6DRK7) Pfam (PF00069) UniProt (by SIFTS) (Q4KMI8) | Danio rerio (Zebrafish) | |
| 2 | B (A) | 4-({1-[3-(3-amino-3-oxopropyl)-5-chlorophenyl]-3-methyl-1H-pyrazolo[4,3-c]pyridin-6-yl}amino)-3-methoxy-N-(1-methylpipe ridin-4-yl)benzamide | non-polymer | 576.1 | 1 | Chemie (5FR) | |||
| 3 | C (A) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 17 - 312 (UniProt: Q6DRK7)
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| Pro 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Asp 196 | Thr 196 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34442.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 576.1 | |
| All* | Total formula weight | 35018.2 |
