3DB6
Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902
Summary for 3DB6
Entry DOI | 10.2210/pdb3db6/pdb |
Related | 3d5u 3d5v 3d5w 3d5x |
Descriptor | Polo-like kinase 1, 1-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]urea (3 entities in total) |
Functional Keywords | polo-like kinase 1, plk1, catalytic domain, small-molecule inhibitor, kinase, transferase |
Biological source | Danio rerio (zebra fish) |
Total number of polymer chains | 1 |
Total formula weight | 34936.57 |
Authors | Elling, R.A.,Fucini, R.V.,Zhu, J.,Barr, K.J.,Romanowski, M.J. (deposition date: 2008-05-30, release date: 2008-08-19, Last modification date: 2023-11-29) |
Primary citation | Elling, R.A.,Fucini, R.V.,Hanan, E.J.,Barr, K.J.,Zhu, J.,Paulvannan, K.,Yang, W.,Romanowski, M.J. Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme. Acta Crystallogr.,Sect.F, 64:686-691, 2008 Cited by PubMed: 18678933DOI: 10.1107/S1744309108019623 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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