3DB6
Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polo-like kinase 1 | polymer | 301 | 34442.1 | 1 | UniProt (Q4KMI8) Pfam (PF00069) | Danio rerio (zebra fish) | |
| 2 | B (A) | 1-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]urea | non-polymer | 494.5 | 1 | Chemie (FRS) | |||
| 3 | C (A) | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A: 17 - 312 (UniProt: Q4KMI8)
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| Pro 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Asp 196 | Thr 196 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34442.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 494.5 | |
| All* | Total formula weight | 34936.6 |
