3DB6

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902

Summary for 3DB6

• Entry DOI: 10.2210/pdb3db6/pdb
• Related: 3d5u 3d5v 3d5w 3d5x
• Descriptor: Polo-like kinase 1, 1-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]urea (3 entities in total)
• Functional Keywords: polo-like kinase 1, plk1, catalytic domain, small-molecule inhibitor, kinase, transferase
• Biological source: Danio rerio (zebra fish)
• Total number of polymer chains: 1
• Total formula weight: 34936.57

Authors

Elling, R.A.,Fucini, R.V.,Zhu, J.,Barr, K.J.,Romanowski, M.J. (deposition date: 2008-05-30, release date: 2008-08-19, Last modification date: 2023-11-29)

• Primary citation: Elling, R.A.,Fucini, R.V.,Hanan, E.J.,Barr, K.J.,Zhu, J.,Paulvannan, K.,Yang, W.,Romanowski, M.J.; Structure of the Brachydanio rerio Polo-like kinase 1 (Plk1) catalytic domain in complex with an extended inhibitor targeting the adaptive pocket of the enzyme.; Acta Crystallogr.,Sect.F, 64:686-691, 2008; PubMed: 18678933; DOI: 10.1107/S1744309108019623

Experimental method

X-RAY DIFFRACTION (2.85 Å)