3DAC

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

3DAC の概要

• エントリーDOI: 10.2210/pdb3dac/pdb
• 関連するPDBエントリー: 1YCR 2Z5S 2Z5T 3DAB
• 分子名称: Mdm4 protein, Cellular tumor antigen p53 (3 entities in total)
• 機能のキーワード: mdmx, mdm4, hdmx, hdm4, mdm-4, mdm-x, mdm2, hdm2, p53, tumor, nucleus, oncogene, apoptosis, cell cycle, disease mutation, dna-binding, transcription
• 由来する生物種: Danio rerio (Zebrafish); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 34346.86

構造登録者

Popowicz, G.M.,Czarna, A.,Holak, T.A. (登録日: 2008-05-29, 公開日: 2008-09-02, 最終更新日: 2023-11-01)

主引用文献

Popowicz, G.M.,Czarna, A.,Holak, T.A.
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
Cell Cycle, 7:2441-2443, 2008

PubMed Abstract: The Mdmx oncoprotein has only recently emerged as a critical-independent to Mdm2-regulator of p53 activation. We have determined the crystal structure of the N-terminal domain of human Mdmx bound to a 15-residue transactivation domain peptide of human p53. The structure shows why antagonists of the Mdm2 binding to p53 are ineffective in the Mdmx-p53 interaction.

PubMed: 18677113
DOI: 10.4161/cc.6365

実験手法

X-RAY DIFFRACTION (1.8 Å)