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3DAC

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0043066biological_processnegative regulation of apoptotic process
A0051726biological_processregulation of cell cycle
M0005634cellular_componentnucleus
M0043066biological_processnegative regulation of apoptotic process
M0051726biological_processregulation of cell cycle
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by CK1, VRK1 and VRK2 => ECO:0000269|PubMed:10606744, ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:31527692
ChainResidueDetails
PTHR18
BTHR18

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CHEK2, CK1 and PLK3 => ECO:0000269|PubMed:10570149, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:20041275
ChainResidueDetails
PSER20
BSER20

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CDK5 and CDK7 => ECO:0000269|PubMed:17591690, ECO:0000269|PubMed:9372954
ChainResidueDetails
PSER33
BSER33

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by MAPKAPK5 => ECO:0000269|PubMed:17254968
ChainResidueDetails
PSER37
BSER37

site_idSWS_FT_FI5
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:21597459
ChainResidueDetails
PLYS24
BLYS24

226707

PDB entries from 2024-10-30

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