3DAC

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (M, A)	Mdm4 protein	polymer	130	14772.7	2	UniProt (Q7ZUW7) Pfam (PF02201)	Danio rerio (Zebrafish)	p53-binding protein Mdm4, Mdm2-like p53-binding protein, Protein Mdmx, Double minute 4 protein
2	B, D (P, B)	Cellular tumor antigen p53	polymer	21	2400.7	2	UniProt (P04637) Pfam (PF08563)		Tumor suppressor p53, Phosphoprotein p53, Antigen NY-CO-13
3	E, F, G, H (M, P, A, B)	water	water		18.0	218	Chemie (HOH)

Sequence modifications

M, A: 15 - 129 (UniProt: Q7ZUW7)

PDB	External Database	Details
Met 0	-	expression tag
Ala 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Val 8	-	expression tag
Asp 9	-	expression tag
Asp 10	-	expression tag
Asp 11	-	expression tag
Asp 12	-	expression tag
Lys 13	-	expression tag
Ile 14	-	expression tag
Val 46	Leu 46	engineered mutation
Leu 95	Val 95	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	34346.9
All*	Total formula weight	34346.9

*Water molecules are not included.