3DA9

Crystal structure of thrombin in complex with inhibitor

3DA9 の概要

• エントリーDOI: 10.2210/pdb3da9/pdb
• 分子名称: Thrombin light chain, Thrombin heavy chain, Hirudin peptide, ... (6 entities in total)
• 機能のキーワード: thrombin, inhibitor complex, acute phase, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, pharmaceutical, polymorphism, protease, secreted, serine protease, zymogen
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35457.33

構造登録者

Xue, Y.,Hansson, S.K. (登録日: 2008-05-29, 公開日: 2009-05-19, 最終更新日: 2024-04-03)

• 主引用文献: Nilsson, M.,Hamalainen, M.,Ivarsson, M.,Gottfries, J.,Xue, Y.,Hansson, S.,Isaksson, R.,Fex, T.; Compounds binding to the S2-S3 pockets of thrombin.; J.Med.Chem., 52:2708-2715, 2009; PubMed: 19371038; DOI: 10.1021/jm8011849

実験手法

X-RAY DIFFRACTION (1.8 Å)