3D8Z
RNase A- 5'-Deoxy-5'-N-pyrrolidinothymidine complex
Summary for 3D8Z
Entry DOI | 10.2210/pdb3d8z/pdb |
Related | 3D8Y |
Descriptor | Ribonuclease pancreatic, 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione, CITRATE ANION, ... (4 entities in total) |
Functional Keywords | ribonuclease, hydrolase, ligand binding, endonuclease, glycation, glycoprotein, nuclease, secreted |
Biological source | Bos taurus (Bovine) |
Cellular location | Secreted: P61823 |
Total number of polymer chains | 2 |
Total formula weight | 27901.09 |
Authors | Leonidas, D.D.,Zographos, S.E.,Oikonomakos, N.G. (deposition date: 2008-05-26, release date: 2009-02-10, Last modification date: 2023-11-01) |
Primary citation | Samanta, A.,Leonidas, D.D.,Dasgupta, S.,Pathak, T.,Zographos, S.E.,Oikonomakos, N.G. Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation J.Med.Chem., 52:932-942, 2009 Cited by PubMed: 19173562DOI: 10.1021/jm800724t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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