3D6T
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
Summary for 3D6T
Entry DOI | 10.2210/pdb3d6t/pdb |
Descriptor | Leucine-rich repeat serine/threonine-protein kinase 2, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | parkinson's disease, lrrk2, roc, roco, gtpase, kinase, atp-binding, disease mutation, gtp-binding, gtpase activation, leucine-rich repeat, membrane, nucleotide-binding, parkinson disease, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Membrane; Peripheral membrane protein: Q5S007 |
Total number of polymer chains | 1 |
Total formula weight | 20270.46 |
Authors | Deng, J. (deposition date: 2008-05-20, release date: 2008-06-10, Last modification date: 2018-02-28) |
Primary citation | Deng, J.,Lewis, P.A.,Greggio, E.,Sluch, E.,Beilina, A.,Cookson, M.R. Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase Proc.Natl.Acad.Sci.Usa, 105:1499-1504, 2008 Cited by PubMed: 18230735DOI: 10.1073/pnas.0709098105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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