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3D6D

Crystal Structure of the complex between PPARgamma LBD and the LT175(R-enantiomer)

3D6D の概要
エントリーDOI10.2210/pdb3d6d/pdb
関連するPDBエントリー1FM9 2Q5S 2Q6S 2REW 3B3K
分子名称Peroxisome proliferator-activated receptor gamma, (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid (3 entities in total)
機能のキーワードbundle of alpha-helices and a small four-stranded beta-sheet, activator, alternative splicing, diabetes mellitus, disease mutation, dna-binding, metal-binding, nucleus, obesity, phosphoprotein, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger
由来する生物種Homo sapiens (Human)
細胞内の位置Nucleus: P37231
タンパク質・核酸の鎖数2
化学式量合計65379.67
構造登録者
Pochetti, G.,Montanari, R. (登録日: 2008-05-19, 公開日: 2008-12-30, 最終更新日: 2023-11-01)
主引用文献Montanari, R.,Saccoccia, F.,Scotti, E.,Crestani, M.,Godio, C.,Gilardi, F.,Loiodice, F.,Fracchiolla, G.,Laghezza, A.,Tortorella, P.,Lavecchia, A.,Novellino, E.,Mazza, F.,Aschi, M.,Pochetti, G.
Crystal Structure of the Peroxisome Proliferator-Activated Receptor gamma (PPARgamma) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design
J.Med.Chem., 51:7768-7776, 2008
Cited by
PubMed: 19053776
DOI: 10.1021/jm800733h
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.4 Å)
構造検証レポート
Validation report summary of 3d6d
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-09-18に公開中

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