3D5X

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with wortmannin.

Summary for 3D5X

Entry DOI	10.2210/pdb3d5x/pdb
Related	3d5u 3d5v 3d5w
Descriptor	Polo-like kinase 1, (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE (2 entities in total)
Functional Keywords	polo-like kinase 1, plk1, catalytic domain, small-molecule inhibitor, kinase, transferase
Biological source	Danio rerio (leopard danio,zebra danio,zebra fish)
Total number of polymer chains	1
Total formula weight	34870.54
Authors	Elling, R.A.,Fucini, R.V.,Romanowski, M.J. (deposition date: 2008-05-17, release date: 2008-08-26, Last modification date: 2023-08-30)
Primary citation	Elling, R.A.,Fucini, R.V.,Romanowski, M.J. Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands. Acta Crystallogr.,Sect.D, 64:909-918, 2008 Cited by PubMed: 18703838 DOI: 10.1107/S0907444908019513 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation