3D5X
Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with wortmannin.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polo-like kinase 1 | polymer | 301 | 34442.1 | 1 | UniProt (Q4KMI8) Pfam (PF00069) | Danio rerio (leopard danio zebra danio zebra fish) | |
| 2 | B (A) | (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE | non-polymer | 428.4 | 1 | Chemie (KWT) PubChem (5691) PubChem (363060) PubChem (44155625) PubChem (44283298) PubChem (44388158) PubChem (71109225) PubChem (58919665) PubChem (70846633) PubChem (71094029) PubChem (73897916) PubChem (3003565) PubChem (6604048) PubChem (6604834) PubChem (6713132) PubChem (312145) PubChem (95566344) PubChem (124543094) PubChem (124583470) PubChem (125039846) PubChem (125039847) PubChem (129010046) PubChem (129010429) PubChem (142863033) PubChem (134688220) PubChem (162901955) PubChem (162901956) PubChem (162901957) PubChem (162901958) |
Sequence modifications
A: 17 - 312 (UniProt: Q4KMI8)
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| Pro 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Asp 196 | Thr 196 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34442.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 428.4 | |
| All* | Total formula weight | 34870.5 |
