3D5X
Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with wortmannin.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Polo-like kinase 1 | polymer | 301 | 34442.1 | 1 | UniProt (Q4KMI8) Pfam (PF00069) In PDB | Danio rerio (leopard danio zebra danio zebra fish) | |
| 2 | A | (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE | non-polymer | 428.4 | 1 | Chemie (KWT) |
Sequence modifications
A: 17 - 312 (UniProt: Q4KMI8)
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| Pro 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Asp 196 | Thr 196 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34442.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 428.4 | |
| All* | Total formula weight | 34870.5 |
