3D5X

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with wortmannin.

3D5X の概要

• エントリーDOI: 10.2210/pdb3d5x/pdb
• 関連するPDBエントリー: 3d5u 3d5v 3d5w
• 分子名称: Polo-like kinase 1, (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE (2 entities in total)
• 機能のキーワード: polo-like kinase 1, plk1, catalytic domain, small-molecule inhibitor, kinase, transferase
• 由来する生物種: Danio rerio (leopard danio,zebra danio,zebra fish)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34870.54

構造登録者

Elling, R.A.,Fucini, R.V.,Romanowski, M.J. (登録日: 2008-05-17, 公開日: 2008-08-26, 最終更新日: 2023-08-30)

• 主引用文献: Elling, R.A.,Fucini, R.V.,Romanowski, M.J.; Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands.; Acta Crystallogr.,Sect.D, 64:909-918, 2008; PubMed: 18703838; DOI: 10.1107/S0907444908019513

実験手法

X-RAY DIFFRACTION (2.8 Å)