3D49

Thrombin Inhibition

Summary for 3D49

• Entry DOI: 10.2210/pdb3d49/pdb
• Related: 1HXF 2ZC9 2ZDA 2ZFP 2ZGX 2ZI2
• Descriptor: Thrombin light chain, Thrombin heavy chain, Hirudin variant-1, ... (6 entities in total)
• Functional Keywords: blood clotting/hydrolase inhibitor, acute phase, blood coagulation, cleavage on pair of basic residues, disease mutation, gamma-carboxyglutamic acid, glycoprotein, kringle, protease, secreted, serine protease, zymogen, blood clotting-hydrolase inhibitor complex
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P01050
• Total number of polymer chains: 3
• Total formula weight: 35463.34

Authors

Baum, B.,Heine, A.,Klebe, G. (deposition date: 2008-05-14, release date: 2009-04-14, Last modification date: 2023-11-15)

• Primary citation: Baum, B.,Hangauer, D.,Heine, A.,Klebe, G.; Understanding Thrombin Inhibition; To be Published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)