3D3V

The complex between TCR A6 and human Class I MHC HLA-A2 with the modified HTLV-1 TAX (Y5(3,4-difluoroPhenylalanine)) peptide

3D3V の概要

• エントリーDOI: 10.2210/pdb3d3v/pdb
• 関連するPDBエントリー: 1AO7 1QRN 1QSE 1QSF 2GJ6 3D39
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Modified HTLV-1 TAX (Y5(3,4-difluoro)F) peptide, ... (7 entities in total)
• 機能のキーワード: htlv-1 tax peptide, 3, 4-difluorophenylalanine, mhc class i, hla-a2, t-cell receptor a6, glycoprotein, host-virus interaction, immune response, membrane, mhc i, phosphoprotein, transmembrane, immunoglobulin domain, secreted, disease mutation, glycation, pyrrolidone carboxylic acid, immune system
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted : P61769
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 94824.93

構造登録者

Borbulevych, O.Y.,Clemens, J.R.,Baker, B.M. (登録日: 2008-05-12, 公開日: 2009-06-16, 最終更新日: 2023-11-15)

• 主引用文献: Piepenbrink, K.H.,Borbulevych, O.Y.,Sommese, R.F.,Clemens, J.,Armstrong, K.M.,Desmond, C.,Do, P.,Baker, B.M.; Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner.; Biochem.J., 423:353-361, 2009; PubMed: 19698083; DOI: 10.1042/BJ20090732

実験手法

X-RAY DIFFRACTION (2.8 Å)