3D1Z

Crystal structure of HIV-1 mutant I54M and inhibitor DARUNAVIR

Summary for 3D1Z

• Entry DOI: 10.2210/pdb3d1z/pdb
• Related: 3CYW 3CYX 3D1X 3D1Y 3D20
• Descriptor: HIV-1 Protease, CHLORIDE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (5 entities in total)
• Functional Keywords: drug resistance; hiv-1, flap mutant, i54m, darunavir, hydrolase
• Biological source: Human immunodeficiency virus type 1 (HIV-1)
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• Total number of polymer chains: 2
• Total formula weight: 22231.51

Authors

Liu, F.,Kovalesky, A.Y.,Tie, Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T. (deposition date: 2008-05-07, release date: 2008-05-27, Last modification date: 2023-08-30)

• Primary citation: Liu, F.,Kovalevsky, A.Y.,Tie, Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T.; Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.; J.Mol.Biol., 381:102-115, 2008; PubMed: 18597780; DOI: 10.1016/j.jmb.2008.05.062

Experimental method

X-RAY DIFFRACTION (1.3 Å)