3D1X

Crystal structure of HIV-1 mutant I54M and inhibitor saquinavir

3D1X の概要

• エントリーDOI: 10.2210/pdb3d1x/pdb
• 関連するPDBエントリー: 3CYW 3CYX 3D1Y 3D1Z 3D20
• 関連するBIRD辞書のPRD_ID: PRD_000454
• 分子名称: HIV-1 Protease, CHLORIDE ION, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, ... (5 entities in total)
• 機能のキーワード: drug resistance, hiv-1, i54m, flap mutant, aids, aspartyl protease, capsid maturation, capsid protein, hydrolase-hydrolase inhibitor complex, viral nucleoprotein, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22386.72

構造登録者

Liu, F.,Weber, I.T. (登録日: 2008-05-06, 公開日: 2008-06-03, 最終更新日: 2023-08-30)

• 主引用文献: Liu, F.,Kovalevsky, A.Y.,Tie, Y.,Ghosh, A.K.,Harrison, R.W.,Weber, I.T.; Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir.; J.Mol.Biol., 381:102-115, 2008; PubMed: 18597780; DOI: 10.1016/j.jmb.2008.05.062

実験手法

X-RAY DIFFRACTION (1.05 Å)