3D08

Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R

3D08 の概要

• エントリーDOI: 10.2210/pdb3d08/pdb
• 関連するPDBエントリー: 3D05 3D06 3D07 3D09 3D0A
• 分子名称: Cellular tumor antigen p53, ZINC ION (3 entities in total)
• 機能のキーワード: p53, mutant protein, loop-sheet-helix motif, acetylation, activator, alternative splicing, anti-oncogene, apoptosis, cell cycle, covalent protein-rna linkage, cytoplasm, disease mutation, dna-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, li-fraumeni syndrome, metal-binding, methylation, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, ubl conjugation, zinc
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22519.92

構造登録者

Suad, O.,Rozenberg, H.,Shimon, L.J.W.,Frolow, F.,Shakked, Z. (登録日: 2008-05-01, 公開日: 2009-01-20, 最終更新日: 2023-11-01)

• 主引用文献: Suad, O.,Rozenberg, H.,Brosh, R.,Diskin-Posner, Y.,Kessler, N.,Shimon, L.J.W.,Frolow, F.,Liran, A.,Rotter, V.,Shakked, Z.; Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations; J.Mol.Biol., 385:249-265, 2009; PubMed: 18996393; DOI: 10.1016/j.jmb.2008.10.063

実験手法

X-RAY DIFFRACTION (1.4 Å)