3D08
Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R
3D08 の概要
エントリーDOI | 10.2210/pdb3d08/pdb |
関連するPDBエントリー | 3D05 3D06 3D07 3D09 3D0A |
分子名称 | Cellular tumor antigen p53, ZINC ION (3 entities in total) |
機能のキーワード | p53, mutant protein, loop-sheet-helix motif, acetylation, activator, alternative splicing, anti-oncogene, apoptosis, cell cycle, covalent protein-rna linkage, cytoplasm, disease mutation, dna-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, li-fraumeni syndrome, metal-binding, methylation, nucleus, phosphoprotein, polymorphism, transcription, transcription regulation, ubl conjugation, zinc |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 22519.92 |
構造登録者 | Suad, O.,Rozenberg, H.,Shimon, L.J.W.,Frolow, F.,Shakked, Z. (登録日: 2008-05-01, 公開日: 2009-01-20, 最終更新日: 2023-11-01) |
主引用文献 | Suad, O.,Rozenberg, H.,Brosh, R.,Diskin-Posner, Y.,Kessler, N.,Shimon, L.J.W.,Frolow, F.,Liran, A.,Rotter, V.,Shakked, Z. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations J.Mol.Biol., 385:249-265, 2009 Cited by PubMed: 18996393DOI: 10.1016/j.jmb.2008.10.063 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.4 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード