3CYO
Structure of a longer thermalstable core domain of HIV-1 GP41 containing the enfuvirtide resistance mutation N43D and complementary mutation E137K
Summary for 3CYO
Entry DOI | 10.2210/pdb3cyo/pdb |
Related | 3CP1 |
Descriptor | Transmembrane protein (2 entities in total) |
Functional Keywords | hiv-1 envelope glycoprotein, 6-helix bundle, gp41, n43d, e137k, aids, apoptosis, coiled coil, envelope protein, fusion protein, host-virus interaction, membrane, transmembrane, virion, viral protein, cleavage on pair of basic residues, lipoprotein, palmitate, viral immunoevasion |
Biological source | Human immunodeficiency virus type 1 More |
Cellular location | Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: Q70626 |
Total number of polymer chains | 1 |
Total formula weight | 9975.19 |
Authors | Wang, Z.M.,Dwyer, J.J. (deposition date: 2008-04-25, release date: 2008-06-17, Last modification date: 2023-08-30) |
Primary citation | Bai, X.,Wilson, K.L.,Seedorff, J.E.,Ahrens, D.,Green, J.,Davison, D.K.,Jin, L.,Stanfield-Oakley, S.A.,Mosier, S.M.,Melby, T.E.,Cammack, N.,Wang, Z.,Greenberg, M.L.,Dwyer, J.J. Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure. Biochemistry, 47:6662-6670, 2008 Cited by PubMed: 18507398DOI: 10.1021/bi702509d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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