3CP1

Structure of a longer thermalstable core domain of HIV-1 gp41 containing the enfuvirtide resistance mutation N43D

Summary for 3CP1

Entry DOI	10.2210/pdb3cp1/pdb
Descriptor	Transmembrane Protein (2 entities in total)
Functional Keywords	hiv-1 envelope glycoprotein, 6-helix bundle, gp41, n43d, aids, apoptosis, coiled coil, envelope protein, fusion protein, host-virus interaction, membrane, transmembrane, virion, viral protein
Biological source	Human immunodeficiency virus 1 More
Cellular location	Surface protein gp120: Virion membrane ; Peripheral membrane protein . Transmembrane protein gp41: Virion membrane ; Single-pass type I membrane protein : Q70626
Total number of polymer chains	1
Total formula weight	9975.12
Authors	Wang, Z.M.,Dwyer, J.J. (deposition date: 2008-03-30, release date: 2008-06-17, Last modification date: 2023-08-30)
Primary citation	Bai, X.,Wilson, K.L.,Seedorff, J.E.,Ahrens, D.,Green, J.,Davison, D.K.,Jin, L.,Stanfield-Oakley, S.A.,Mosier, S.M.,Melby, T.E.,Cammack, N.,Wang, Z.,Greenberg, M.L.,Dwyer, J.J. Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure. Biochemistry, 47:6662-6670, 2008 Cited by PubMed: 18507398 DOI: 10.1021/bi702509d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation