3CYO

Structure of a longer thermalstable core domain of HIV-1 GP41 containing the enfuvirtide resistance mutation N43D and complementary mutation E137K

3CYO の概要

• エントリーDOI: 10.2210/pdb3cyo/pdb
• 関連するPDBエントリー: 3CP1
• 分子名称: Transmembrane protein (2 entities in total)
• 機能のキーワード: hiv-1 envelope glycoprotein, 6-helix bundle, gp41, n43d, e137k, aids, apoptosis, coiled coil, envelope protein, fusion protein, host-virus interaction, membrane, transmembrane, virion, viral protein, cleavage on pair of basic residues, lipoprotein, palmitate, viral immunoevasion
• 由来する生物種: Human immunodeficiency virus type 1; 詳細
• 細胞内の位置: Transmembrane protein gp41: Virion membrane; Single-pass type I membrane protein. Surface protein gp120: Virion membrane; Peripheral membrane protein: Q70626
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9975.19

構造登録者

Wang, Z.M.,Dwyer, J.J. (登録日: 2008-04-25, 公開日: 2008-06-17, 最終更新日: 2023-08-30)

• 主引用文献: Bai, X.,Wilson, K.L.,Seedorff, J.E.,Ahrens, D.,Green, J.,Davison, D.K.,Jin, L.,Stanfield-Oakley, S.A.,Mosier, S.M.,Melby, T.E.,Cammack, N.,Wang, Z.,Greenberg, M.L.,Dwyer, J.J.; Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure.; Biochemistry, 47:6662-6670, 2008; PubMed: 18507398; DOI: 10.1021/bi702509d

実験手法

X-RAY DIFFRACTION (2.1 Å)