3CY3

Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V

3CY3 の概要

• エントリーDOI: 10.2210/pdb3cy3/pdb
• 関連するPDBエントリー: 3CXW 3CY2
• 分子名称: Serine/threonine-protein kinase pim-1, Pimtide peptide, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: oncogene, kinase, serine-threonine, pim1, structural genomics consortium, sgc, alternative initiation, atp-binding, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, host-virus interaction, viral immunoevasion, virion, virulence
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37827.02

構造登録者

Filippakopoulos, P.,Bullock, A.,Fedorov, O.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2008-04-25, 公開日: 2008-07-15, 最終更新日: 2024-10-30)

• 主引用文献: Filippakopoulos, P.,Bullock, A.,Fedorov, O.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.; Proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and the JNK inhibitor V.; To be Published,

実験手法

X-RAY DIFFRACTION (2.15 Å)