3CXW
Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand I
Summary for 3CXW
Entry DOI | 10.2210/pdb3cxw/pdb |
Related | 3CY2 3CY3 |
Descriptor | Proto-oncogene serine/threonine-protein kinase Pim-1, Isoform 2, Pimtide peptide, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | oncogene, kinase, serine-threonine, pim1, structural genomics consortium, sgc, alternative initiation, atp-binding, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, host-virus interaction, viral immunoevasion, virion, virulence |
Biological source | Homo sapiens More |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
Total number of polymer chains | 2 |
Total formula weight | 37725.25 |
Authors | Filippakopoulos, P.,Bullock, A.,Fedorov, O.,Huber, K.,Bracher, F.,Pike, A.C.W.,Roos, A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-04-25, release date: 2008-07-15, Last modification date: 2023-08-30) |
Primary citation | Huber, K.,Brault, L.,Fedorov, O.,Gasser, C.,Filippakopoulos, P.,Bullock, A.N.,Fabbro, D.,Trappe, J.,Schwaller, J.,Knapp, S.,Bracher, F. 7,8-Dichloro-1-oxo-beta-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes J.Med.Chem., 55:403-413, 2012 Cited by PubMed: 22136433DOI: 10.1021/jm201286z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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