3CY2
Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand II
3CY2 の概要
エントリーDOI | 10.2210/pdb3cy2/pdb |
関連するPDBエントリー | 3CXW 3CY3 |
分子名称 | Proto-oncogene serine/threonine-protein kinase Pim-1, Isoform 2, Pimtide peptide, CHLORIDE ION, ... (6 entities in total) |
機能のキーワード | oncogene, kinase, serine-threonine, pim1, structural genomics consortium, sgc, alternative initiation, atp-binding, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, host-virus interaction, viral immunoevasion, virion, virulence |
由来する生物種 | Homo sapiens 詳細 |
細胞内の位置 | Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 37738.85 |
構造登録者 | Filippakopoulos, P.,Bullock, A.,Fedorov, O.,Huber, K.,Bracher, F.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2008-04-25, 公開日: 2008-07-15, 最終更新日: 2023-08-30) |
主引用文献 | Huber, K.,Brault, L.,Fedorov, O.,Gasser, C.,Filippakopoulos, P.,Bullock, A.N.,Fabbro, D.,Trappe, J.,Schwaller, J.,Knapp, S.,Bracher, F. 7,8-Dichloro-1-oxo-beta-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes J.Med.Chem., 55:403-413, 2012 Cited by PubMed: 22136433DOI: 10.1021/jm201286z 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.01 Å) |
構造検証レポート
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