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3CY2

Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand II

3CY2 の概要
エントリーDOI10.2210/pdb3cy2/pdb
関連するPDBエントリー3CXW 3CY3
分子名称Proto-oncogene serine/threonine-protein kinase Pim-1, Isoform 2, Pimtide peptide, CHLORIDE ION, ... (6 entities in total)
機能のキーワードoncogene, kinase, serine-threonine, pim1, structural genomics consortium, sgc, alternative initiation, atp-binding, manganese, membrane, metal-binding, nucleotide-binding, nucleus, phosphoprotein, proto-oncogene, serine/threonine-protein kinase, transferase, host-virus interaction, viral immunoevasion, virion, virulence
由来する生物種Homo sapiens
詳細
細胞内の位置Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
タンパク質・核酸の鎖数2
化学式量合計37738.85
構造登録者
主引用文献Huber, K.,Brault, L.,Fedorov, O.,Gasser, C.,Filippakopoulos, P.,Bullock, A.N.,Fabbro, D.,Trappe, J.,Schwaller, J.,Knapp, S.,Bracher, F.
7,8-Dichloro-1-oxo-beta-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes
J.Med.Chem., 55:403-413, 2012
Cited by
PubMed: 22136433
DOI: 10.1021/jm201286z
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.01 Å)
構造検証レポート
Validation report summary of 3cy2
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-09-18に公開中

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