3CY2
Crystal structure of human proto-oncogene serine threonine kinase (PIM1) in complex with a consensus peptide and a beta carboline ligand II
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene serine/threonine-protein kinase Pim-1, Isoform 2 | polymer | 314 | 35719.7 | 1 | UniProt (P11309) Pfam (PF00069) | Homo sapiens | |
| 2 | B (B) | Pimtide peptide | polymer | 14 | 1592.8 | 1 | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile | non-polymer | 328.8 | 1 | Chemie (MB9) | |||
| 5 | E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | F, G (A, B) | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A: 1 - 313 (UniProt: P11309)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Gly 250 | Arg 250 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37312.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 426.3 | |
| All* | Total formula weight | 37738.8 |
