3CU8
Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome
Summary for 3CU8
Entry DOI | 10.2210/pdb3cu8/pdb |
Descriptor | 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | 14-3-3, zeta, adapter protein, craf1, noonan syndrome, leopard syndrome, phosphoprotein, protein binding, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : P63104 P04049 |
Total number of polymer chains | 4 |
Total formula weight | 57836.96 |
Authors | Schumacher, B.,Weyand, M.,Kuhlmann, J.,Ottmann, C. (deposition date: 2008-04-16, release date: 2009-05-05, Last modification date: 2017-10-25) |
Primary citation | Molzan, M.,Schumacher, B.,Ottmann, C.,Baljuls, A.,Polzien, L.,Weyand, M.,Thiel, P.,Rose, R.,Rose, M.,Kuhenne, P.,Kaiser, M.,Rapp, U.R.,Kuhlmann, J.,Ottmann, C. Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling. Mol. Cell. Biol., 30:4698-4711, 2010 Cited by PubMed: 20679480DOI: 10.1128/MCB.01636-09 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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