3CU8
Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | 14-3-3 protein zeta/delta | polymer | 245 | 27777.1 | 2 | UniProt (P63104) Pfam (PF00244) | Homo sapiens (Human) | 14-3-3 zeta adapter protein, Protein kinase C inhibitor protein 1, KCIP-1 |
| 2 | C, D (P, Q) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 9 | 1080.0 | 2 | UniProt (P04049) | Homo sapiens | Raf-1, C-RAF, cRaf |
| 3 | E, G (A, Q) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | F (A) | PROPANOIC ACID | non-polymer | 74.1 | 1 | Chemie (PPI) | |||
| 5 | H, I, J, K (A, B, P, Q) | water | water | 18.0 | 196 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57714.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 122.7 | |
| All* | Total formula weight | 57837.0 |
