3CU8

Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome

3CU8 の概要

• エントリーDOI: 10.2210/pdb3cu8/pdb
• 分子名称: 14-3-3 protein zeta/delta, RAF proto-oncogene serine/threonine-protein kinase, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: 14-3-3, zeta, adapter protein, craf1, noonan syndrome, leopard syndrome, phosphoprotein, protein binding, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cytoplasm : P63104 P04049
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 57836.96

構造登録者

Schumacher, B.,Weyand, M.,Kuhlmann, J.,Ottmann, C. (登録日: 2008-04-16, 公開日: 2009-05-05, 最終更新日: 2017-10-25)

• 主引用文献: Molzan, M.,Schumacher, B.,Ottmann, C.,Baljuls, A.,Polzien, L.,Weyand, M.,Thiel, P.,Rose, R.,Rose, M.,Kuhenne, P.,Kaiser, M.,Rapp, U.R.,Kuhlmann, J.,Ottmann, C.; Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling.; Mol. Cell. Biol., 30:4698-4711, 2010; PubMed: 20679480; DOI: 10.1128/MCB.01636-09

実験手法

X-RAY DIFFRACTION (2.4 Å)