3CPW

The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI

3CPW の概要

• エントリーDOI: 10.2210/pdb3cpw/pdb
• 分子名称: 23S RIBOSOMAL RNA, 50S ribosomal protein L10e, 50S ribosomal protein L13P, ... (40 entities in total)
• 機能のキーワード: linezolid, 50s ribosomal subunit, antibiotic complexes, ribonucleoprotein, ribosomal protein, rna-binding, rrna-binding, trna-binding, metal-binding, zinc-finger, ribosome
• 由来する生物種: HALOARCULA MARISMORTUI; 詳細
• 細胞内の位置: Cytoplasm : P12743
• タンパク質・核酸の鎖数: 31
• 化学式量合計: 1474423.98

構造登録者

Ippolito, J.A.,Kanyo, Z.K.,Wang, D.,Franceschi, F.J.,Moore, P.B.,Steitz, T.A.,Duffy, E.M. (登録日: 2008-04-01, 公開日: 2008-07-22, 最終更新日: 2024-02-21)

主引用文献

Ippolito, J.A.,Kanyo, Z.K.,Wang, D.,Franceschi, F.J.,Moore, P.B.,Steitz, T.A.,Duffy, E.M.
Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit
J.Med.Chem., 51:3353-3356, 2008

PubMed Abstract: The oxazolidinone antibacterials target the 50S subunit of prokaryotic ribosomes. To gain insight into their mechanism of action, the crystal structure of the canonical oxazolidinone, linezolid, has been determined bound to the Haloarcula marismortui 50S subunit. Linezolid binds the 50S A-site, near the catalytic center, which suggests that inhibition involves competition with incoming A-site substrates. These results provide a structural basis for the discovery of improved oxazolidinones active against emerging drug-resistant clinical strains.

PubMed: 18494460
DOI: 10.1021/jm800379d

実験手法

X-RAY DIFFRACTION (2.7 Å)